RING ENLARGEMENT BY ALKYLATED 3-HYDROXYBUTYRATES - A SYNTHESIS OF (12S, 13R)-(-)-12-METHYL-13-TETRADECANOLIDE

Authors
KRAFT P TOCHTERMANN W
Citation
P. Kraft et W. Tochtermann, RING ENLARGEMENT BY ALKYLATED 3-HYDROXYBUTYRATES - A SYNTHESIS OF (12S, 13R)-(-)-12-METHYL-13-TETRADECANOLIDE, Tetrahedron, 51(40), 1995, pp. 10875-10882
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
40
Year of publication
1995
Pages
10875 - 10882
Database
ISI
SICI code
0040-4020(1995)51:40<10875:REBA3->2.0.ZU;2-N
Abstract
TBS-protected iodo alkohols 6 were prepared via Frater alkylation and applied in the synthesis of optically active macrolides 5 and 10. By r ing enlargement of cyclodecanone (7) the superposition molecule 5 of t wo macrocyclic odorants was synthesized and a conformationally fixed t ricyclic macrolide 11 constructed.