REGIOSPECIFIC GENERATION AND APPLICATION OF 3-LITHIOMETHYL-2-METHYL-1-PHENYLPYRAZOLIN-5-ONE AS 1,3-BINUCLEOPHILE IN AROMATIC ANNELATION - ANOVEL-APPROACH FOR SYNTHESIS OF 1,2-DISUBSTITUTED INDAZOLONES AND THEIR CONDENSED ANALOGS

Authors
REDDY KR ROY A ILA H JUNJAPPA H
Citation
Kr. Reddy et al., REGIOSPECIFIC GENERATION AND APPLICATION OF 3-LITHIOMETHYL-2-METHYL-1-PHENYLPYRAZOLIN-5-ONE AS 1,3-BINUCLEOPHILE IN AROMATIC ANNELATION - ANOVEL-APPROACH FOR SYNTHESIS OF 1,2-DISUBSTITUTED INDAZOLONES AND THEIR CONDENSED ANALOGS, Tetrahedron, 51(40), 1995, pp. 10941-10952
Citations number
44
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
40
Year of publication
1995
Pages
10941 - 10952
Database
ISI
SICI code
0040-4020(1995)51:40<10941:RGAAO3>2.0.ZU;2-Y
Abstract
The enolate anion 5A generated by deprotonation of 2,3-dimethyl- 1-phe nylpyrazolin-5-one is shown to undergo highly regioselective gamma-1,4 -addition to alpha-oxoketene dithioacetals followed by cycloaromatizat ion in the presence of boron trifluoride etherate to afford wide range of novel substituted and condensed indazolones in good yields.