FURTHER BROMINATED BIS-INDOLE AND TRIS-INDOLE ALKALOIDS FROM THE DEEP-WATER NEW-CALEDONIAN MARINE SPONGE ORINA SP

Two tris-indole alkaloids, (+/-)-gelliusines A and B [1], have been is olated for the first time from a marine source, the New Caledonian spo nge, Orina sp. (or Gellius sp.), along with five further indole consti tuents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-i ndolyl)-ethylamine, previously isolated from the tunicate Didemnum can didum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.