SYNTHETIC STUDIES ON BROMOCOUMARINS POSSE SSING OXYGEN FUNCTION

Authors
NISHIOKA H HAYASHIDA N KAWABE S HARAYAMA T
Citation
H. Nishioka et al., SYNTHETIC STUDIES ON BROMOCOUMARINS POSSE SSING OXYGEN FUNCTION, Yakugaku zasshi, 115(9), 1995, pp. 765-772
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Yakugaku zasshi → ACNP
ISSN journal
00316903
Volume
115
Issue
9
Year of publication
1995
Pages
765 - 772
Database
ISI
SICI code
0031-6903(1995)115:9<765:SSOBPS>2.0.ZU;2-F
Abstract
The reaction of bromo-methoxysalicylaldehyde (4-6) and broma-hydroxysa licylaldehyde (18) with carbethoxymethylenetriphenylphosphorane (2) in diethylaniline under reflux gave unexpected debromocoumarins along wi th an expected bromocoumarin. The oxygen function might facilitate deb romination in the process of coumarin synthesis at an elevated tempera ture.