Md. Stetter et Ca. Peloquin, ISONIAZID AND RIFAMPIN SERUM LEVELS IN A COLOBUS MONKEY (COLOBUS-GUEREZA-CAUDATUS) INFECTED WITH MYCOBACTERIUM-BOVIS, Journal of zoo and wildlife medicine, 26(1), 1995, pp. 152-154
A Mycobacterium bovis culture-positive, skin test-negative, colobus mo
nkey (Colobus guereza caudatus) was treated with three different dosag
e regimens of isoniazid (INH) and rifampin (RIE). Blood samples were c
ollected over various time periods and serum INH and RIF concentration
s were determined. Antituberculous treatment dosages for other nonprim
ates and for humans were inadequate to achieve therapeutic serum conce
ntrations in this colobus monkey.