COMBINATION THERAPY WITH MUCOSAL PROTECTIVE AGENT FOR THE ERADICATIONOF HELICOBACTER-PYLORI

Objective: To investigate the effect of plaunotol in combination with proton-pump inhibitors on Helicobacter pylori eradication in patients with gastric ulcer. Patients and methods: We studied 65 H. pylori-posi tive gastric ulcer patients. They were randomly assigned to five treat ment groups: omeprazole (group I, n=8), lansoprazole (group II, n=13), lansoprazole+plaunotol (group III, n=12), lansoprazole + clarithromyc in (group IV, n=16) and lansoprazole + plaunotol + clarithromycin (gro up V, n=16). Ulcer status was diagnosed by endoscopy and H. pylori sta tus by culture, histology, a urease test and a urea breath test at bas eline, and after 8 and 12 weeks. The clearance and eradication rates w ere compared in each group. Results: The healing rates in groups I-V w ere 100, 92, 100, 100 and 100%, respectively; clearance rates were 0, 23, 42, 50 and 75%, respectively; and eradication rates were 0, 0, 8, 38 and 69%, respectively. Conclusion: Combination therapy with plaunot ol is efficacious for the eradication of H, pylori in gastric ulcer pa tients.