CALCULATING THERAPEUTIC INDEXES AND THERAPEUTIC ADVANTAGES FOR ENDOTOXINS AND MONOPHOSPHORYL LIPID-A - AN EVALUATION OF DATA FROM THE SCIENTIFIC LITERATURE

This review article addresses the question of whether or not monophosp horyl lipid A offers a therapeutic advantage over smaller doses of end otoxin, Biological data were collected from a literature review and th ese were used to calculate therapeutic indices for monophosphoryl lipi d A and endotoxin. Subsequent calculations yielded results which showe d that, in humans and in other animals, monophosphoryl lipid A did hav e a therapeutic advantage over smaller doses of endotoxin.