1-AZASPIRO[4.4]NONANE-2,6-DIONE AND THE SEPARATION AND ABSOLUTE-CONFIGURATIONS OF ITS ENANTIOMERS

Authors
NAGASAKA T SATO H SAEKI S
Citation
T. Nagasaka et al., 1-AZASPIRO[4.4]NONANE-2,6-DIONE AND THE SEPARATION AND ABSOLUTE-CONFIGURATIONS OF ITS ENANTIOMERS, Tetrahedron : asymmetry, 8(2), 1997, pp. 191-194
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
2
Year of publication
1997
Pages
191 - 194
Database
ISI
SICI code
0957-4166(1997)8:2<191:1ATSAA>2.0.ZU;2-W
Abstract
Racemic 1-azaspiro[4.4]nonane-2,6-dione 1 was easily synthesized from cyclopentanone in five steps and resolved via chiral acetals into enan tiomers. Cephlotaxine (-)-3 and its enantiomer (+)-3 were obtained fro m (-)-1 and (+)-1, respectively, according to the literature. (C) 1997 Published by Elsevier Science Ltd.