SIGNIFICANCE OF DIFFERENT PROGNOSTIC FACT ORS FOR LOCALLY CONFINED RENAL-CELL CARCINOMAS

The significance of tumor stage, malignancy grade, Ki-67, PCNA (Prolif erating Cell Nuclear Antigen), H-3-thymidine labeling index, tumor plo idy as well as tumor growth after xenotransplantation into nude mice ( GAX range) has been examined by following the fate of a total of 41 pa tients with a locally confined renal cell carcinoma after nephrectomy (mean follow-up time 5.2 years). Using the single factor analysis tumo r stage, malignancy grade, Ki-67, and GAX range were found to be signi ficant prognostic parameters with respect to both survival and tumor r ecurrence. Applying the multivariate analysis the combination of the ' 'new'' factors shows even a higher prognostic relevance than that of t he two ''classic'' factors tumor stage and malignancy grade. The calcu lated prognostic index based on tumor stage, malignancy grade and Ki-6 7 showed a considerably higher prognostic validity than that of the tw o conventional prognosticators.