ACETYL-L-CARNITINE ATTENUATES NEURONAL DAMAGE IN GERBILS WITH TRANSIENT FOREBRAIN ISCHEMIA ONLY WHEN GIVEN BEFORE THE INSULT

The underlying mechanisms leading to neuronal damage in cerebral ische mia are multifactoral. Ln this study, we evaluated the neuroprotective effects of acetyl-L-carnitine, a medication that may enhance metaboli c recovery after cerebral ischemia. The 5-minute transient forebrain i schemia model in gerbils was used. Acetyl-L-carnitine was given 30 min utes before the insult in one set of animals and 30 minutes after the insult in a second set of animals with histological evaluation at 7 da ys (Group A) and 28 days (Group B). Damage assessment was done using a 4-point damage score and Mann-Whitney U test was used for statistical analysis. Compared to the controls, there was significant protection in the cerebral cortex, hippocampus and the striatum in animals treate d with the medication before the insult in Group A and Group B. Post-i schemic therapy showed little evidence of neuronal protection in eithe r group. Behavioral tests in the Group B animals showed no significant differences between the treated or the saline controls. Our study sho ws, that pre-ischemic treatment with acetyl-L-carnitine results in neu ronal protection. This may have clinical significance in situations (s uch as bypass surgery) where treatment could be initiated prior to the insult.