NEW COMPRESSED TABLET RAPIDLY DISINTEGRATING IN SALIVA IN THE MOUTH USING CRYSTALLINE CELLULOSE AND A DISINTEGRANT

We formulated a new compressed tablet which is rapidly disintegrated a nd dissolved in the mouth without the need to drink water. The crushin g strength increased with increasing compression force and maximum val ues (8-18 kgf) for the formulations comprising crystalline cellulose a nd low-substituted hydroxypropylcellulose (L-HPC) were obtained at the compression force of 300 kgf. Rapid disintegration (within 30 s) was obtained in vitro using various compounding ratios of crystalline cell ulose to L-HPC. Tablets prepared with crystalline cellulose and L-HPC rapidly disintegrated in saliva (small amount of water) in the mouth o f humans.