Y. Watanabe et al., NEW COMPRESSED TABLET RAPIDLY DISINTEGRATING IN SALIVA IN THE MOUTH USING CRYSTALLINE CELLULOSE AND A DISINTEGRANT, Biological & pharmaceutical bulletin, 18(9), 1995, pp. 1308-1310
We formulated a new compressed tablet which is rapidly disintegrated a
nd dissolved in the mouth without the need to drink water. The crushin
g strength increased with increasing compression force and maximum val
ues (8-18 kgf) for the formulations comprising crystalline cellulose a
nd low-substituted hydroxypropylcellulose (L-HPC) were obtained at the
compression force of 300 kgf. Rapid disintegration (within 30 s) was
obtained in vitro using various compounding ratios of crystalline cell
ulose to L-HPC. Tablets prepared with crystalline cellulose and L-HPC
rapidly disintegrated in saliva (small amount of water) in the mouth o
f humans.