A NEW SYNTHESIS OF 1-HYDROXYINDOLES AND SPECTRA OF 1-HYDROXYINDOLE

Authors
HENMI T SAKAMOTO T KIKUGAWA Y
Citation
T. Henmi et al., A NEW SYNTHESIS OF 1-HYDROXYINDOLES AND SPECTRA OF 1-HYDROXYINDOLE, Heterocycles, 44, 1997, pp. 157-163
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
44
Year of publication
1997
Pages
157 - 163
Database
ISI
SICI code
0385-5414(1997)44:<157:ANSO1A>2.0.ZU;2-4
Abstract
Partial reduction of 1-[2-(trimethylsilyl)ethoxy]-2-oxindole (3) with AlH(iso-Bu)(2) (DIBAL) and subsequent removal of the protecting group with (n-Bu)(4)NF affords 1-hydroxyindole (1) in sufficiently pure form to produce reliable spectral data (nmr, ms, and uv) for the first tim e; this methodology is applicable to the synthesis of other 1-hydroxyi ndoles.