PRACTICAL SYNTHESIS OF (S)-3-(P-NITROBENZYLOXYCARBONYLAMINO)PYRROLIDINE AND ITS RELATED-COMPOUNDS FROM L-APARTIC ACID

Authors
TOMORI H SHIBUTANI K OGURA K
Citation
H. Tomori et al., PRACTICAL SYNTHESIS OF (S)-3-(P-NITROBENZYLOXYCARBONYLAMINO)PYRROLIDINE AND ITS RELATED-COMPOUNDS FROM L-APARTIC ACID, Heterocycles, 44, 1997, pp. 213-225
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
44
Year of publication
1997
Pages
213 - 225
Database
ISI
SICI code
0385-5414(1997)44:<213:PSO(>2.0.ZU;2-P
Abstract
An efficient method for the preparation of (S)-3-aminopyrrolidine deri vatives was developed starting from L-aspartic acid, which involves an efficient formation of a pyrrolidine-ring from allylamine and a pract ical Pd/C-catalyzed cleavage of N-allyl protective group. This method affords the enantiomerically pure desired compounds (1) in high overal l yields.