SYNTHESIS OF LENNOXAMINE VIA THE INTRAMOLECULAR CYCLIZATION OF ALKYNYLAMIDE

Authors
KOSEKI Y NAGASAKA T
Citation
Y. Koseki et T. Nagasaka, SYNTHESIS OF LENNOXAMINE VIA THE INTRAMOLECULAR CYCLIZATION OF ALKYNYLAMIDE, Chemical and Pharmaceutical Bulletin, 43(9), 1995, pp. 1604-1606
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
9
Year of publication
1995
Pages
1604 - 1606
Database
ISI
SICI code
0009-2363(1995)43:9<1604:SOLVTI>2.0.ZU;2-4
Abstract
This paper presents the formal synthesis of lennoxamine (1), the key s tep [4 into 10 via 9] of which is a novel palladium-catalyzed coupling reaction followed by intramolecular cyclization of alkynylamide.