M. Rubenstein et al., ORTHOTOPIC PLACEMENT OF THE DUNNING R3327 AT-3 PROSTATE TUMOR IN THE COPENHAGEN X FISCHER RAT, The Prostate, 27(3), 1995, pp. 148-153
Orthotopic placement of in vitro propagated Dunning R3327 AT-3 tumor c
ells resulted in a greater percentage of tumor takes and a two-fold sh
ift in the exponential growth curve compared to flank implantation. Th
e orthotopic tumor appeared to disseminate preferentially to regional
lymph nodes, rather than to the lungs which is characteristic of flank
tumors. The results suggest an important role of stromal-epithelial i
nteractions in the growth of this tumor. (C) 1995 Wiley-Liss, Inc.