FLUCONAZOLE TREATMENT OF CANDIDA-ALBICANS INFECTION IN MICE - DOES IN-VITRO SUSCEPTIBILITY PREDICT IN-VIVO RESPONSE

A series of fluconazole-susceptible and-fluconazole resistant Candida albicans fungal isolates mere used to infect mice intravenously. Mice were treated with varying doses of fluconazole beginning one day after infection. For all of the 6 fluconazole-susceptible isolates, flucona zole was highly effective at <0.25 mg/kg of body weight twice daily. B y contrast, fluconazole was less effective in at least 6 of 10 flucona zole-resistant isolates and was ineffective at greater than or equal t o 40 mg/kg twice daily in 4 fluconazole-resistant isolates. Although t he correlation is not precise, in vitro susceptibility testing of C. a lbicans can predict in vivo response to fluconazole.