IN-VITRO ANTIBACTERIAL ACTIVITY AND BETA-LACTAMASE STABILITY OF A NEWCARBAPENEM, BO-2727

The in vitro activity of BO-2727, a new carbapenem, was compared with those of meropenem, biapenem, imipenem, and ceftazidime. BO-2727 was f our- or eightfold more active than the other carbapenems against methi cillin-resistant staphylococci and Pseudomonas aeruginosa strains, inc luding imipenem- and ceftazidime-resistant bacteria. BO-2727 was quite stable to penicillinases, cephalosporinases, and oxyiminocephalospori nases, but not to metallo-beta-lactamase. Time-kill studies against St aphylococcus aureus Smith, Escherichia coli ML4707, and P. aeruginosa GN11189 showed that BO-2727 has potent bactericidal activity at concen trations greater than the MIC.