PHARMACOKINETICS OF 51W89 - PRELIMINARY DATA

Citation
Jm. Hunter et al., PHARMACOKINETICS OF 51W89 - PRELIMINARY DATA, Acta anaesthesiologica Scandinavica, 39, 1995, pp. 94-94
Citations number
3
Categorie Soggetti
Anesthesiology
ISSN journal
00015172
Volume
39
Year of publication
1995
Supplement
106
Pages
94 - 94
Database
ISI
SICI code
0001-5172(1995)39:<94:PO5-PD>2.0.ZU;2-G
Abstract
The pharmacokinetics of the 1R cis-1'R cis-isomer of atracurium (51W89 ) acid its metabolite, laudanosine, were studied in 11 healthy patient s with normal renal function and in 12 patients with chronic renal fai lure undergoing regular dialysis. A bolus dose of 51W89 (0.1 mg/kg) wa s given, and the plasma concentration was measured at regular interval s for 480 min. The elimination half-life of 51W89 was significantly lo nger in renal failure patients than in healthy controls (38.9 min vs 3 0.6 min; P<0.05). The plasma laudanosine levels were lower than those reported after an equipotent dose of atracurium besylate. 51W89 may ha ve a prolonged effect in renal failure patients.