Objective: To review the evaluation and management of delirium in elde
rly patients for primary-care providers. Design: We summarize the clin
ical features, course, pathophysiologic aspects, predisposing factors,
causes, and differential diagnosis of delirium and discuss approaches
to affected patients and various management strategies. Results: Deli
rium, an altered mental state, occurs more frequently in elderly than
in younger patients. The pathophysiologic changes associated with agin
g and the higher occurrence of multiple medical problems and need for
medications contribute to the higher frequency of delirium in elderly
patients. Evaluation should begin with a consideration of the most com
mon causes, such as a change in or addition to prescribed medications,
a withdrawal from alcohol or other sedative-hypnotic drugs, an infect
ion, or a sudden change in neurologic, cardiac, pulmonary, or metaboli
c state. Finally, management of delirium is threefold: (1) identifying
and treating underlying causes, (2) nonpharmacologic interventions, a
nd (3) pharmacologic therapies to manage symptoms of delirium. Conclus
ion: Elderly patients frequently experience delirium. Delirious sympto
ms can produce devastating consequences if they are not recognized and
appropriately treated.