We have studied flux line confinement by regular arrays of submicron h
oles (triangular and square antidot lattices) in superconducting films
. Critical current density j(c) and pinning force f(p) are very strong
ly enhanced due to pinning of single or multi-quanta vortices by the a
ntidots. Direct measurements of j(c) and f(p) for several well-defined
antidot diameters D, proves that pinning centers with size considerab
ly larger than the temperature-dependent coherence length xi(T) are mu
ch more efficient than those with D congruent to xi(T).