SERUM CONCENTRATIONS OF IL-5, GM-CSF, AND IL-3 AND THE PRODUCTION BY LYMPHOCYTES IN VARIOUS EOSINOPHILIA

The concentrations of interleukin-5 (IL-5), granulocyte-macrophage col ony-stimulating factor GM-CSF, and interleukin-3 (IL-3) in serum and i n IL-2-stimulated lymphocyte culture medium (L-IL2-CM) prepared from p atients with reactive eosinophilia were measured by enzyme-linked immu nosorbent assay (ELISA), Serum IL-5 levels were increased in 16 out of 42 cases, GM-CSF and IL-3 were below the detectable levels in all ser a examined, The concentrations of IL-5 and GM-CSF in L-IL2-CM were inc reased in 10 out of 29 patients, IL-3 was below the detectable levels in all L-ILS-CM. (C) 1995 Wiley-Liss, Inc.