STEROID-RESPONSIVE PULMONARY DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROMES WITH DER(1Q-7P) CHROMOSOMAL ABNORMALITY

We report three patients with pulmonary disorders associated with myel odysplastic syndromes (MDS), All three patients had symptoms of pyrexi a and respiratory discomfort, One patient had pulmonary eosinophilia w ith bilateral pleural effusion, one had interstitial pneumonia, and on e had bilateral pleural effusion caused by systemic vasculitis. Elevat ed C-reactive protein (CRP) levels, polyclonal hypergammaglobulinemia, and morphological abnormalities in peripheral blood were observed in all three patients. The bone marrow of these patients revealed triline age dysplasia and eosinophilia, Cytogenetic analysis showed [46,XY,-7, +der(1q;7p)]. Antibiotic treatment was not effective, However, improve ment was dramatic after corticosteroid treatment; CRP levels were redu ced and the hypergammaglobulinemia was improved, These cases suggest t hat MDS with [-7,+der(1q;7p)] may be correlated with bone marrow eosin ophilia and that an immunologic abnormality may be involved in the pul monary disorders. (C) 1995 Wiley-Liss, Inc.