COMPLICATIONS OF INVASIVE, URODYNAMIC EXAMINATIONS AND PROSTATE BIOPSIES IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

We studied 85 men with moderate to severe symptoms of benign prostatic hyperplasia (BPH) who completed two placebo-controlled studies of dru g therapy. During the 48 week period of treatment and follow-up the pa tients underwent 164 procedures which included urethral instrumentatio n, predominantly without antibiotic prophylaxis, and 187 procedures of urethral instrumentation in combination with transperineal prostate b iopsy with antibiotic prophylaxis. The risk for a patient to acquire c linically significant urinary tract infection was 2.4% after urethral instrumentation alone and 7.5% when urethral instrumentation was combi ned with prostate biopsy. Invasive urodynamic examinations of prostate biopsies in studies of new treatment modalities for BPH should only b e performed when necessary to obtain important information, and after full informed patient consent. The combination of prostate biopsy and urethral instrumentation increases the infection rate considerably and should be avoided.