STRONG ASSOCIATION BETWEEN THE RESPONDER STATUS OF THE FC-GAMMA-II RECEPTOR AND RECURRENT SPONTANEOUS-ABORTION

Citation
A. Lorenz et al., STRONG ASSOCIATION BETWEEN THE RESPONDER STATUS OF THE FC-GAMMA-II RECEPTOR AND RECURRENT SPONTANEOUS-ABORTION, European journal of immunogenetics, 22(5), 1995, pp. 397-401
Citations number
18
Categorie Soggetti
Immunology,"Genetics & Heredity
ISSN journal
09607420
Volume
22
Issue
5
Year of publication
1995
Pages
397 - 401
Database
ISI
SICI code
0960-7420(1995)22:5<397:SABTRS>2.0.ZU;2-2
Abstract
Several models exist for the aetiology and therapy of recurrent sponta neous abortion (RSA). They are based in part on the assumption that an increased materno-fetal histocompatibility results in an insufficient maternal immunological recognition of the fetus, and thus renders the maternal immune system unable to sustain the pregnancy. The involveme nt of the Fc gamma II receptor (Fc gamma IIR) in RSA was suggested, si nce Fc gamma IIR-blocking antibodies, present in normal pregnancies, c ould not be found in patients suffering from RSA. The Fc gamma IIR is known to be functionally and structurally dimorphic, which results in a responder, respectively non-responder pattern. We used an in vitro p roliferation assay to distinguish between Fc gamma IIR responder and n on-responder phenotypes. In 29 RSA couples we found 97% (28/29) of RSA patients and 100% (29/29) of their partners to be responders, whereas 50 fertile couples and a further 100 unrelated controls revealed dist ributions of responder vs. non-responder of 73% vs. 27% and 70% vs. 30 %, respectively. These differences (RSA vs. controls) are highly signi ficant (P less than or equal to 0.0001). Our results suggest further t hat the Fc gamma IIR dimorphism might be involved in the pathogenesis of RSA.