DIAGNOSTIC AND THERAPEUTIC ERRORS IN CHRO NIC LYMPHOID LEUKEMIA (CLL)

The analysis of 67 cases of benign, progressive, tumor CLL, lymph node lymphocytoma, CLL sarcoma transformation showed that the cases were m isdiagnosed in 35.8% cases. The most common mistake (25:4%) was aggres sive chemotherapy based on histological diagnosis of prolymphocytic, p rolymphocytic-lymphoblastic lymphosarcoma without consideration of cyt ological and clinical evidence, tumor phenotype. The authors think val id to use the following criteria in diagnosis of lymphoproliferative d iseases: histological findings, clinical manifestations and blood pict ure, tumor cell cytology, primary location and predominant disseminati on of the tumor, immunophenotype, characteristic chromosomal disorders , response to treatment.