EMODIN PHARMACOKINETICS IN RABBITS

Administration of emodin to rabbits by i.v. bolus resulted in a serum profile which could be well described by a two-compartment model. The AUC of emodin was 518 mu g . min/ml clearance was 72.3 ml/min, and eli mination half life was 227 min which was much longer than that reporte d in a previous study. Oral administration of emodin resulted in a ver y low serum concentration. Protein binding of emodin was investigated by the equilibrium dialysis method. Emodin was found to be highly boun d (99.6%) to serum protein.