SEX-CHROMOSOME ANEUPLOIDY AND AGING

Loss of an X chromosome in females and of the Y chromosome in males ar e phenomena associated with aging. X chromosome loss occurs in and may be limited to PHA stimulated peripheral lymphocytes. In males, the lo ss of the Y is most evident in bone marrow cells, but also occurs to a lesser extent in PHA stimulated peripheral lymphocytes. X chromosome loss is associated with premature centromere division leading to anaph ase lag and elimination in micronuclei. The mechanism of Y chromosome loss has not been elucidated. No pathological consequence of either X or Y chromosome loss has been convincingly demonstrated. With the adve nt of FISH technology, measurement of sex chromosome aneuploidy may pr ove to be a convenient assay for cellular senecence and aging.