CONTINUOUS-INFUSION ETOPOSIDE CARBOPLATIN FOR TREATMENT OF REFRACTORYACUTE-LEUKEMIA/

Authors
LETENDRE L NOEL P TEFFERI A SOLBERG LA GASTINEAU DA HOAGLAND HC
Citation
L. Letendre et al., CONTINUOUS-INFUSION ETOPOSIDE CARBOPLATIN FOR TREATMENT OF REFRACTORYACUTE-LEUKEMIA/, American journal of clinical oncology, 18(5), 1995, pp. 382-384
Citations number
9
Categorie Soggetti
Oncology
Journal title
American journal of clinical oncology → ACNP
ISSN journal
02773732
Volume
18
Issue
5
Year of publication
1995
Pages
382 - 384
Database
ISI
SICI code
0277-3732(1995)18:5<382:CECFTO>2.0.ZU;2-S
Abstract
Etoposide (125 mg/m(2)/d) and carboplatin (200 mg/m(2)/d) were adminis tered by continuous 5-day intravenous infusion to 10 patients with rel apsed or refractory acute leukemia (7 ANLL, 1 ALL, 2 blast crisis of C GL). No complete or partial response was observed despite dose-limitin g toxicity characterized by severe diarrhea in four patients and neutr openic colitis in two additional cases. We cannot recommend the presen t schedule of drug administration for the treatment of acute leukemia.