ACUTE MYOCARDIAL-INFARCTION IN MAN TREATED WITH EPIRUBICIN FOR NON-HODGKIN-LYMPHOMA

This article presents a young patient affected with non-Hodgkin lympho ma who developed acute myocardial infarction 7 days after treatment wi th epirubicin (90 mg/m(2), day 1), cyclophosphamide (600 mg/m(2), day 1), vincristine (2 mg, day 1), prednisolone (100 mg, days 1-5), and on dansetron (3 X 4 mg/day, days 1-2). Six months after the myocardial in farction the patient had no further cardiac complications after treatm ent with the cyclophosphamide, vincristine, and ondansetron chemothera py regimen. Epirubicin was considered to play an important role in the production of infarction, and the probable mechanisms of epirubicin-i nduced myocardial infarction are discussed.