SYNTHESIS OF DERIVATIVES OF 3-ACETYL-2-AMINOPYRROLE AND PYRROLO[2,3-D]PYRIMIDINE FROM MONOACETYLKETENE AMINALS

A new scheme for the synthesis of pyrrolo[2,3-d]pyrimidines from monoa cetylketene animals was proposed. Reactions of monoacetylketene N-benz oyl- and N-acetylaminals with alpha-bromoacetophenone afforded the cor responding 3-acetyl-2-acylamino-5-phenyl-1 H-pyrroles, which underwent cyclization to 2,4,6-trisubstituted 7H-pyrrolo[2,3-d]pyrimidines unde r the action of ammonium acetate in boiling BuOH.