Lm. Likhosherstov et al., SYNTHESIS OF N-CHLOROACETYL-BETA-GLYCOPYRANOSYLAMINES, DERIVATIVES OFMONOSACCHARIDES AND LACTOSE, Russian chemical bulletin, 45(7), 1996, pp. 1760-1763
N-Chloroacetyl-beta-glycosylamines were synthesized from various monos
accharides (hexoses, pentoses, deoxysugars, uronic acids, and sugar ph
osphates) and a disaccharide (lactose) by N-acylation of the correspon
ding beta-glycosylamines with chloroacetic anhydride in DMF. In some c
ases, treatment of monosaccharides with NH3 in the presence of (NH4)CO
3 in MeOH or aqueous MeOH was more efficient than the methods previous
ly described, as it gave beta-glycosylamines in higher yields.