HIGH-YIELD SYNTHESIS OF HIGH-PURITY [F-18] LABELED AROMATIC-COMPOUNDSBY ARYL F-FOR-X HALOGEN EXCHANGE-REACTIONS

Authors
HASHIZUME K HASHIMOTO N CORK DG MIYAKE Y
Citation
K. Hashizume et al., HIGH-YIELD SYNTHESIS OF HIGH-PURITY [F-18] LABELED AROMATIC-COMPOUNDSBY ARYL F-FOR-X HALOGEN EXCHANGE-REACTIONS, Chemistry Letters, (9), 1995, pp. 835-836
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
9
Year of publication
1995
Pages
835 - 836
Database
ISI
SICI code
0366-7022(1995):9<835:HSOH[L>2.0.ZU;2-E
Abstract
The relative efficacy of aromatic fluorine-for-halogen (F-X) exchange reactions was found to be F-F > F-Cl > F-Br > F-I in a [F-18]fluoride- cryptand-oxalate system using 4'-haloacetophenones (F, Cl, Br and I), key intermediates for many F-18-radiopharmaceuticals. Efficient F-18-l abelling reaction and a new chromatographic separation method has enab led the potential of F-for-X exchange (X=Cl and F) to be realized for the high yield synthesis of high purity [F-18]-neuroleptics.