GENE METHYLATION OF ESTROGEN AND EPIDERMAL GROWTH-FACTOR RECEPTORS INNEOPLASTIC AND PERINEOPLASTIC BREAST TISSUES

Authors
PETRANGELI E LUBRANO C RAVENNA L VACCA A CARDILLO MR SALVATORI L SCIARRA F FRATI L GULINO A
Citation
E. Petrangeli et al., GENE METHYLATION OF ESTROGEN AND EPIDERMAL GROWTH-FACTOR RECEPTORS INNEOPLASTIC AND PERINEOPLASTIC BREAST TISSUES, British Journal of Cancer, 72(4), 1995, pp. 973-975
Citations number
16
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
72
Issue
4
Year of publication
1995
Pages
973 - 975
Database
ISI
SICI code
0007-0920(1995)72:4<973:GMOEAE>2.0.ZU;2-D
Abstract
Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) ge ne methylation was evaluated in neoplastic and perineoplastic breast t issues from 20 patients. In both tissues, ER gene methylation was inve rsely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic ti ssues, suggesting a significant role in neoplastic transformation.