SERUM GLYCATED LIPOPROTEINS IN TYPE-II DIABETIC-PATIENTS WITH AND WITHOUT COMPLICATIONS

The extent of lipoprotein glycation was assessed in 82 patients diagno sed as diabetes mellitus type II. Glycated lipoprotein levels in serum were determined by agarose gel film electrophoresis in 48 non-diabeti c control subjects, 56 diabetics with complications and 26 diabetics w ith no complications. All glycated lipoproteins were higher in the pat ients when the diabetics were compared to the control group, but glyca ted very low-density lipoprotein (VLDL) was the only glycated lipoprot ein fraction that was observed to be higher in the diabetic patients w ith complications compared to the patients without complications (P < 0.01). Triglycerides and VLDL-cholesterol were also increased in the d iabetics, but there was no significant difference in these variables w hen the patients without complications were compared to the control su bjects. There was no difference in total cholesterol and low-density l ipoprotein (LDL)-cholesterol levels of the diabetic patients compared to the controls.