NO LITHOLYTIC EFFECT OF ZNSO4 AND CUSO4 O N EXPERIMENTAL LITHIASIS INRATS

Seventy two male Wistar-strain rats were fed lithogenic diet with ethy lene-glycol within three weeks. At the end of this treatment, six rats were killed in order to determine the oxalate and calcium concentrati ons in renal tissue. Remained rats was randomly divided in four series , each serie consisting of three groups. In first serie (T), the anima ls were treated with distilled water; in the second (D1Zn), the animal s were treated intramuscularly with the zinc at the rate of 24 mu g pe r 100 grams of body weight and per day, in the third (D2Zn), 240 mu g of zinc were administrated to animals and in the last serie (D2Cu), th e animals were treated at the same dose as the previous serie, but wit h the copper. The groups wich making up each serie were killed success ively at the 5 th, 10 th and 15 th day after ending treatment with eth yleneglycol in order to determine urinary pH, percentage of water in r enal tissue, uremia and concentrations of oxalate and calcium in renal tissue. Then, the comparisons of means were carried out, at each time , between different treated groups and reference group wich was treate d with distilled water. Litholytic effect was found in all series, inc luding that which had been treated with distilled water. However, comp ared to reference animals, no acceleration of litholytic process was i nduced by zinc or copper. The high doses used in these experimentation s proved therefore that calcium oxalate calculi were insoluble by zinc and copper.