Background. We compared the long-term costs and outcomes of gastric by
pass versus medical therapy (very dow-calorie diet plus weekly behavio
ral modification) for obese patients. Methods. A successful outcome wa
s defined as the loss of at least one third of excess weight that was
maintained for the duration of the study. A minimal cost was assigned:
$3000 for medical and $24,000 for surgical treatment. A cost per poun
d of weight lost for all patients successfully monitored was calculate
d. The Federal Trade Commission recently asked all weight loss program
s to report this cost for patients at least 2 years after therapy. Res
ults. A total of 201 patients entered surgical and 161 entered medical
therapy. The surgical group was initially heavier (mean body mass ind
ex [kg/m(2)] +/- SE = 49.3 +/- 0.6 versus 41.2 +/- 0.7, p < 0.01), but
each group's lowest mean body mass index was similar (31.8 versus 32.
1, respectively). A significantly higher percentage of patients in the
surgical versus the medical group were still successful at year 5: 89
% versus 21%. The cost per pound lost for medical therapy exceeded the
cost of surgical therapy in the sixth posttreatment year (both more t
han $250/pound). Conclusions. Surgical treatment appears to be more co
st-effective at producing and maintaining weight loss. It is imperativ
e that long-term follow-up studies be funded to definitely establish t
his finding.