MICROTUBULE DYNAMICS - TAKING AIM AT A MOVING TARGET

Authors
WILSON L JORDAN MA
Citation
L. Wilson et Ma. Jordan, MICROTUBULE DYNAMICS - TAKING AIM AT A MOVING TARGET, Chemistry & biology, 2(9), 1995, pp. 569-573
Citations number
26
Categorie Soggetti
Biology
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
2
Issue
9
Year of publication
1995
Pages
569 - 573
Database
ISI
SICI code
1074-5521(1995)2:9<569:MD-TAA>2.0.ZU;2-#
Abstract
Antitumor drugs of the vinca alkaloid and taxane classes function by s uppressing the dynamics of microtubules in spindles, blocking cell div ision at metaphase. The drugs bind to various sites on the tubulin dim er and at different positions within the microtubule, suggesting that there are many unexplored targets for the design of novel drugs of thi s type.