BONE-DENSITY, VITAMIN-D NUTRITION, AND PARATHYROID-HORMONE LEVELS IN WOMEN WITH DEMENTIA

OBJECTIVE: To determine whether patients with dementia have reduced bo ne mass, altered vitamin D, or parathyroid hormone status. DESIGN: Sur vey. SETTING: University hospital outpatient department. PARTICIPANTS: Twenty women with DSM-III-R mild dementia living in the community wer e compared with 40 cognitively normal community-dwelling women, matche d for age, who had been recruited as part of studies in elderly twins. MEASUREMENTS: Bone density at the lumbar spine and neck of femur by d ual-energy X-ray absorptiometry, intact serum PTH, and 25-hydroxyvitam in D levels. MAIN RESULTS: There was no significant-difference in bone density between the subjects with mild dementia and the age-and sex-m atched controls. The intact PTH (mean +/- SD) in the demented subjects was 4.9 +/- 2.1 pmol/L compared with 2.9 +/- 1.7 pmol/L in the twin c ontrols (P < .01). The mean 25-hydroxyvitamin D in the demented subjec ts was 61 +/- 33 nmol/L, whereas it was 90 +/- 38 nmol/L in the twin c ontrols (P < .01). CONCLUSIONS: We conclude that there were no signifi cant differences in the bone density of community-dwelling women with mild dementia compared with normals. However, there were significant d ifferences in parathyroid hormone and vitamin D levels between the two groups, suggesting that there is a high prevalence of subclinical hyp ovitaminosis D in demented women in the community.