SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SEVERAL FLUORINATED ARTEMISININ DERIVATIVES

The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosul fur trifluoride. A number of other mono- and polyfluorinated artemisin in derivatives were prepared. Their in vitro antimalarial activities w ere all equal to or greater than the nonfluorinated analogs or precurs ors.