TC-99M-METHOXY-ISOBUTYL-ISONITRILE (SESTAMIBI) IMAGING OF MALIGNANT CANINE LYMPHOMA

Technetium-99m methoxy-isobutyl-isonitrile (sestamibi) imaging of mali gnant canine lymphoma was performed in thirteen dogs 1 hour after intr avenous injection of Tc-99m-sestamibi at 13 MBq (0.35 mCi) per kilogra m body weight, Abnormal tracer uptake was visualized in the liver, spl een, bone marrow, and mesenteric, inguinal, popliteal, sternal, crania l cervical and mandibular lymph nodes. Radiopharmaceutical uptake was also noted in a nasal mass. One large neoplastic renal mass did not ha ve demonstrable sestamibi uptake, Other regions had no significant dif ference in the target:background ratios when compared with values from normal dogs (P > 0.05), Tc-99m-sestamibi can be used to image maligna nt lymphoma, and has potential applications in the management of patie nts to document response to treatment and to stage of extent of diseas e.