THE ROLE OF BSAP (PAX-5) IN B-CELL DEVELOPMENT

Authors
BUSSLINGER M URBANEK P
Citation
M. Busslinger et P. Urbanek, THE ROLE OF BSAP (PAX-5) IN B-CELL DEVELOPMENT, Current opinion in genetics & development, 5(5), 1995, pp. 595-601
Citations number
53
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
5
Issue
5
Year of publication
1995
Pages
595 - 601
Database
ISI
SICI code
0959-437X(1995)5:5<595:TROB(I>2.0.ZU;2-B
Abstract
The hierarchy of transcriptional control in B-cell development has rec ently been analyzed by targeted gene inactivation in the mouse. In thi s manner, the paired box containing gene Pax-5, encoding the B cell sp ecific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and trans cription of the immunoglobulin heavy-chain gene at late stages of B-ce ll differentiation.