SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF A NOVEL TRIPEPTIDE MIMETIC DOPAMINE PRODRUG

Authors
WANG HP LEE JS TSAI MC LU HH HSU WL
Citation
Hp. Wang et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF A NOVEL TRIPEPTIDE MIMETIC DOPAMINE PRODRUG, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2195-2198
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
19
Year of publication
1995
Pages
2195 - 2198
Database
ISI
SICI code
0960-894X(1995)5:19<2195:SAPAOA>2.0.ZU;2-O
Abstract
D-p-hydroxyphenylglycine-L-proline was attached to L-dopa as delivery tool for improving the oral absorption. This tripeptide prodrug 1 of d opamine was well absorbed in a perfusion study in rat intestine, devoi d of dopamine-like side effects on isolated smooth muscles and signifi cantly inhibited the (+)-methamphetamine-induced rotation in nigrostri atal-lesioned rats, suggesting of anti-Parkinsonism effect.