SYNTHESIS OF 1-O-ALKYL-MYO-INOSITOL 3,4,5-TRISPHOSPHATES AND 1-O-ACYL-MYO-INOSITOL 3,4,5-TRISPHOSPHATES AS NOVEL ANALOGS OF PHOSPHATIDYL-MYO-INOSITOL 3,4,5-TRISPHOSPHATE

Authors
SAWADA T SHIRAI R MATSUO Y KABUYAMA Y KIMURA K FUKUI Y HASHIMOTO Y IWASAKI S
Citation
T. Sawada et al., SYNTHESIS OF 1-O-ALKYL-MYO-INOSITOL 3,4,5-TRISPHOSPHATES AND 1-O-ACYL-MYO-INOSITOL 3,4,5-TRISPHOSPHATES AS NOVEL ANALOGS OF PHOSPHATIDYL-MYO-INOSITOL 3,4,5-TRISPHOSPHATE, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2263-2266
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
19
Year of publication
1995
Pages
2263 - 2266
Database
ISI
SICI code
0960-894X(1995)5:19<2263:SO13A1>2.0.ZU;2-4
Abstract
Homochiral 1-O-alkyl and 1-O-acyl derivatives of myo-inositol 3,4,5-tr isphosphate were designed and synthesized as novel analogues of phosph atidyl-myo-inositol 3,4,5-trisphosphate. 1-O-Octadecyl and 1-O-stearoy l analogues inhibited the synthesis of phosphatidyl-myo-inositol 3,4-b isphosphate from phosphatidyl-myo-inositol 3,4,5-trisphosphate catalyz ed by PIns-3,4,5-P-3 5-phosphatase. These compounds may act as competi tors in the enzyme reaction, suggesting that they may be useful in stu dies of the role of phosphatidyl-myo-inositol 3,4,5-trisphosphate as a candidate second messenger in cellular signal transduction.