SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF A-80426 - A PUTATIVE NOVEL ANTIDEPRESSANT COMBINING ALPHA-2 ANTAGONISM WITH 5-HT UPTAKE INHIBITION

Authors
MEYER MD HANCOCK AA TIETJE K SIPPY KB GIARDINA WJ KERWIN JF
Citation
Md. Meyer et al., SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF A-80426 - A PUTATIVE NOVEL ANTIDEPRESSANT COMBINING ALPHA-2 ANTAGONISM WITH 5-HT UPTAKE INHIBITION, Bioorganic & medicinal chemistry letters, 5(19), 1995, pp. 2287-2292
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
19
Year of publication
1995
Pages
2287 - 2292
Database
ISI
SICI code
0960-894X(1995)5:19<2287:SAPCOA>2.0.ZU;2-I
Abstract
A-80426, 4-tetrahydronaphthalen-1-yl-methyl]-N-methylamine) represents the first example of a new structural class of agents combining poten t alpha-2 antagonist activity with equivalent 5-HT uptake inhibitory a ctivity. This profile of combined activities may have utility in the t reatment of depression.