INVESTIGATION OF POTENTIAL ONCOGENETIC EFFECTS OF BETA-CYCLODEXTRIN IN THE RAT AND MOUSE

The results of oncogenicity studies of beta-cyclodextrin in inbred Fis cher 344 rats and CD-1 outbred mice are presented. Chronic feeding of beta-cyclodextrin to Fischer 344 rats and CD-1 mice did not cause any treatment related carcinogenic effects. The only toxic effect was seen in mice as macroscopic distension of the large intestine with soft or fluid contents, histologically associated with the mucosa covered by mucous secretion containing exfoliated cells, and mucosal flattening a nd intestinal gland atrophy. Despite these observations, no difference s between control and treated groups were observed concerning mortalit y, clinical observations or body weight and food consumption.