K. Mizumura et al., INFLUENCE OF HISTAMINE ON THE BRADYKININ RESPONSE OF CANINE TESTICULAR POLYMODAL RECEPTORS IN-VITRO, Inflammation research, 44(9), 1995, pp. 376-378
Effects of histamine on the testicular polymodal receptors were studie
d in vitro using canine testis-spermatic nerve preparations. Histamine
induced distinct increase in the discharge rate in 6 out of 17 units
tested (high responders), while it only weakly excited the remaining 1
1 units (low responders). The bradykinin response of low responders te
nded to be slightly facilitated by pretreatment with histamine, while
that of high responders tended to be suppressed. Significant correlati
on was observed between the magnitude of histamine-induced discharges
and the magnitude of change in the bradykinin responses.