COMBINED TREATMENT WITH ENURESIS ALARM AND DESMOPRESSIN FOR NOCTURNALENURESIS

Seventy-one children with nocturnal enuresis were enrolled in a contro lled trial. The children were allocated to two matched groups. Childre n in both groups used an enuresis alarm until the end of treatment. Ch ildren in the first group were treated with 40 mu g of intranasal desm opressin (Desmospray) for up to 6 weeks at the start of treatment with the alarm. During the observation period before treatment there were 2.3 dry nights per week in both groups. At the end of treatment there was a significant difference in the mean number of dry nights per week between the two groups (6.3 in the alarm and desmopressin group and 4 .8 in the alarm group) and also in the number of children becoming rel iably dry. The combination of desmopressin and alarm was particularly helpful for children with severe wetting and those with family and beh avioural problems.