SYNTHESIS OF ALLYLIC TRIFLUOROMETHYL ALCOHOLS FROM 1-TRIFLUOROMETHYL-EPOXY ETHERS

Authors
BEGUE JP BONNETDELPON D KORNILOV A FISCHERDURAND N
Citation
Jp. Begue et al., SYNTHESIS OF ALLYLIC TRIFLUOROMETHYL ALCOHOLS FROM 1-TRIFLUOROMETHYL-EPOXY ETHERS, Journal of fluorine chemistry, 80(1), 1996, pp. 13-16
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of fluorine chemistry → ACNP
ISSN journal
00221139
Volume
80
Issue
1
Year of publication
1996
Pages
13 - 16
Database
ISI
SICI code
0022-1139(1996)80:1<13:SOATAF>2.0.ZU;2-3
Abstract
alpha-Thiophenyl ketones are easily available by the regioselective ri ng-opening of 1-trifluoromethyl-epoxy ethers with phenyl sodium thiola te. Their in situ reduction with NaBH4, followed by oxidation with NaI O4 and thermal decomposition of the resultant sulphoxides, provided al lylic trifluoromethyl alcohols in high overall yield.