[TC-99M]TRICINE - A USEFUL PRECURSOR COMPLEX FOR THE RADIOLABELING OFHYDRAZINONICOTINATE PROTEIN CONJUGATES

Authors
LARSEN SK SOLOMON HF CALDWELL G ABRAMS MJ
Citation
Sk. Larsen et al., [TC-99M]TRICINE - A USEFUL PRECURSOR COMPLEX FOR THE RADIOLABELING OFHYDRAZINONICOTINATE PROTEIN CONJUGATES, Bioconjugate chemistry, 6(5), 1995, pp. 635-638
Citations number
10
Categorie Soggetti
Biology,Chemistry,"Biochemical Research Methods
Journal title
Bioconjugate chemistry → ACNP
ISSN journal
10431802
Volume
6
Issue
5
Year of publication
1995
Pages
635 - 638
Database
ISI
SICI code
1043-1802(1995)6:5<635:[-AUPC>2.0.ZU;2-7
Abstract
The stannous reduction of [Tc-99m]pertechnetate in the presence of tri cine results in the formation of the new labeling precursor complex [T c-99m]tricine. This complex has improved efficacy for the Tc-99m label ing of hydrazinonicotinate-modified IgG compared to [Tc-99m]glucohepto nate. FAB mass spectral analysis of the product formed by the reaction of [TcOCl4](-1) with tricine indicates the formation of [TcO(tricine- 2H)(2)](-1).