LOCALIZATION OF MYOCARDIAL-ISCHEMIA FROM THE MAGNETOCARDIOGRAM USING CURRENT-DENSITY RECONSTRUCTION METHOD - COMPUTER-SIMULATION STUDY

A computer simulation study is performed to investigate the method of current density reconstruction to localise myocardial ischaemia. A com puter model of the entire human heart is used to simulate the excitati on and repolarisation process in eight topographically different cases of myocardial ischaemia, The associated magnetocardiogram is calculat ed at 37 positions of the KRENIKON biomagnetic measurement equipment. The method of current density reconstruction is applied at the S-poin t (the last discernible deviation from the ST-segment at the end of th e QRS-complex) of the MCG to find characteristics of the myocardial is chaemia simulated by the model. The results show that it is possible t o determine the location of the ischaemia. The current density distrib ution may be interpreted physiologically in terms of the so-called 'in jury current'. This indicates that magnetocardiography might be a suit able method for noninvasive ischaemia diagnosis, and further investiga tions of the current density reconstruction method for the injury curr ent should be performed on patients with ischaemic heart disease,